LCMS使用液相色谱作为分离系统,质谱作为检测系统。 样品在质谱部分与流动相分离。 离子碎片被电离后,由质谱仪的质量分析器根据荷质比进行分离,由检测器得到质谱图。 LCMS可以分析GCMS无法分析的强极性、难挥发、热不稳定的化合物,具有分析范围广、分析能力强、定性分析结果可靠、检测限低等优点。
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